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Oxycodone/Acetaminophen Product Information

Specification	Details
Brand Names	Percocet®, Endocet®, Roxicet®, others
Composition	Oxycodone Hydrochloride (opioid agonist) + Acetaminophen (non-opioid analgesic)
Standard Concentrations	Typically 2.5-10mg oxycodone with 325-650mg acetaminophen per tablet
Duration of Effects	Analgesic effects: 4-6 hours (depending on formulation and individual metabolism)
Primary Indications	Short-term management of acute pain severe enough to require opioid treatment
Administration Method	Oral administration with adequate water; may be taken with food to reduce nausea
Shelf Life	Typically 24-36 months from manufacturing date when stored properly
Storage Conditions	Store at 20-25°C (68-77°F); protect from moisture; keep in original container
Packaging Contents	Prescription bottle with child-resistant cap, containing medication and information leaflet
Country of Origin	Varies by manufacturer; multiple FDA-approved manufacturing facilities globally
Regulatory Status	Schedule II controlled substance (U.S.), similar restrictions internationally
Safety Notes	Boxed warning for addiction potential, respiratory depression, and acetaminophen hepatotoxicity; contraindicated with significant respiratory depression, acute asthma, GI obstruction

$200.00 – $1,350.00

Price Options 10 & 7.5 mg

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Introduction to Oxycodone/Acetaminophen Combination

Oxycodone/acetaminophen combination tablets represent a significant pharmaceutical intervention for managing severe acute pain when non-opioid alternatives prove inadequate. As a prescription medication containing both an opioid analgesic and a non-opioid pain reliever, this combination requires informed medical supervision and responsible usage protocols to balance therapeutic benefits against potential risks. Understanding this medication’s pharmacology, proper indications, and safety considerations is essential for both healthcare professionals and educated patients navigating pain management options.

Pharmacological Profile and Mechanism of Action

This medication combines two distinct analgesic components working through different pathways:

Oxycodone Component: As a semi-synthetic opioid agonist, oxycodone binds primarily to mu-opioid receptors in the central nervous system. This binding produces analgesic effects by modulating pain perception and emotional response to pain. The substance demonstrates approximately 1.5 times the potency of morphine when administered orally, with effects typically beginning within 15-30 minutes and peaking at approximately one hour.

Acetaminophen Component: Operating through central inhibition of prostaglandin synthesis, acetaminophen provides additional analgesic synergy while offering antipyretic properties. The combination allows for lower opioid dosing while maintaining analgesic efficacy, potentially reducing certain opioid-related side effects.

Approved Medical Indications and Clinical Applications

Oxycodone/acetaminophen is specifically indicated for the short-term management of acute pain severe enough to require opioid treatment when alternative treatments are insufficient. Clinical applications include:

Post-surgical pain management following significant procedures
Pain control following major traumatic injuries
Management of acute exacerbations in chronic pain conditions (with careful monitoring)
Cancer-related pain when other options are inadequate

It is crucial to recognize that this medication is not appropriate for mild or intermittent pain, nor as an as-needed medication for chronic pain conditions without comprehensive pain management planning. The limited duration of use is emphasized in clinical guidelines due to the risks associated with long-term opioid therapy and acetaminophen exposure.

Safety Considerations and Risk Mitigation

Opioid-Specific Risks

Respiratory Depression: The most serious acute risk, particularly at higher doses or when combined with other central nervous system depressants
Physical Dependence and Addiction Potential: Even with therapeutic use, physiological adaptation can occur, requiring careful tapering when discontinuing
Cognitive and Motor Impairment: Patients must avoid driving or operating machinery until effects are understood
Gastrointestinal Effects: Constipation, nausea, and vomiting are common and may require proactive management

Acetaminophen-Specific Risks

Hepatotoxicity: Serious liver damage may occur with excessive doses, with risk increasing substantially when exceeding 4,000mg daily
Drug Interactions: Numerous medications contain acetaminophen, creating potential for unintentional overdose
Alcohol Interaction: Concurrent alcohol use significantly increases hepatotoxicity risk

Responsible Usage Guidelines and Patient Education

Patients prescribed oxycodone/acetaminophen should receive comprehensive education covering:

Dosage Adherence: Strictly follow prescribed dosage and frequency without adjustment
Duration Limitations: Use only for the prescribed duration despite potential desire for continued therapy
Storage Security: Maintain in locked containers away from children, visitors, or household members
Disposal Protocol: Properly dispose of unused medication through approved take-back programs
Interaction Awareness: Disclose all medications, supplements, and substances to prescribers
Side Effect Recognition: Identify concerning symptoms requiring immediate medical attention
Tolerance Monitoring: Regularly assess effectiveness with healthcare providers

Conclusion: Balancing Pain Relief and Safety

Oxycodone/acetaminophen represents a powerful tool in the pain management arsenal when used appropriately under rigorous medical supervision. The balance between adequate pain control and medication risks requires ongoing assessment, patient education, and adherence to clinical guidelines. By understanding both the therapeutic potential and substantial risks associated with this medication, healthcare providers and informed patients can work collaboratively toward safe, effective pain management while minimizing potential harms.

For comprehensive information about responsible medication use, visit our educational homepage at Health Aid Pharmacy.

Price Options 10 & 7.5 mg	60 TABS, 100 TABS, 300 TABS, 500 TABS

Ingredients

Skimmed milk powder, lactose, vegetable oils (palm, rapeseed, sunflower), palm kernel fat, calcium carbonate, calcium salts of phosphoric acid, vitamin C, ferrous sulphate, stabilizer: L (+) - lactic acid, vitamin D, riboflavin , vitamin A, potassium iodate.

Nutritional values