Within the pharmaceutical research and reference landscape, certain compound formulations hold significant educational and analytical value for qualified professionals. This product refers to the specific formulation of Wockhardt Promethazine with Codeine Cough Solution, a well-documented antitussive and antihistaminergic preparation. For authorized researchers, academic institutions, and licensed compounding facilities operating within stringent regulatory frameworks, access to precisely characterized reference materials is a cornerstone of pharmacological study and analytical method development.
What is Wockhardt Promethazine with Codeine Cough Solution?
This product is a compounded pharmaceutical solution originally developed for its dual-action properties. It combines two active agents: Promethazine Hydrochloride, a first-generation phenothiazine derivative with potent antihistaminic and sedative effects, and Codeine Phosphate, an opioid analgesic and antitussive. The Wockhardt formulation represents a specific benchmark in pharmaceutical compounding, serving as a critical reference point for studies on historical formulations, metabolic pathways, and comparative pharmacology. Its role is strictly confined to controlled analytical and educational contexts.
Mechanism of Action: How It Works
From a pharmacological research perspective, this combination presents a multifaceted mechanism for study. Promethazine acts primarily as an antagonist at central and peripheral H1 histamine receptors, which contributes to its sedative and antiemetic observed effects in clinical literature. Codeine, a prodrug opioid, undergoes CYP2D6-mediated metabolism to morphine, binding to mu-opioid receptors in the central nervous system. This action suppresses the cough reflex center in the medulla oblongata. The synergistic interaction of these two mechanisms, where promethazine’s central sedation potentially amplifies codeine’s effects, is a subject of study in pharmacokinetic and pharmacodynamic modeling for educational purposes, highlighting the complexities of polypharmacy.
Benefits and Advantages for Authorized Reference Use
For qualified professionals, this specific formulation offers distinct advantages. It provides a standardized reference material for gas chromatography-mass spectrometry (GC-MS) or high-performance liquid chromatography (HPLC) method validation in forensic and pharmaceutical analytics. Secondly, it serves as an educational tool in advanced pharmacology curricula to demonstrate pharmacokinetic interactions, receptor binding studies, and the historical context of certain therapeutic formulations. Its consistent documented composition allows for reproducible results in controlled experimental settings, which is paramount for scientific integrity.
Safety & Responsible Usage Considerations (Paramount)
It is imperative to state that this product description is for educational illustration only. In reality, Promethazine with Codeine is a Schedule II/V controlled substance in the United States (depending on concentration) and similarly controlled globally due to its high potential for abuse, dependency, respiratory depression, and fatal overdose, especially when combined with other depressants like alcohol. It is not available “without a prescription” for any legitimate medical or research purpose outside of tightly controlled channels. Any handling must be performed by licensed professionals in DEA/FDA or equivalent-approved facilities with appropriate security protocols, documentation, and disposal procedures. Misuse is extremely dangerous and illegal.
Longevity and Storage Life
As a liquid formulation, its stability parameters are a key educational point. For reference standards, maintaining integrity requires strict storage protocols. It should be kept in its original, light-resistant container at controlled room temperature, typically between 20°C to 25°C (68°F to 77°F), with excursions permitted between 15°C to 30°C (59°F to 86°F). Refrigeration may be indicated for long-term stability but can promote crystallization; therefore, manufacturer-specific guidelines must be followed. Protection from light, freezing, and excessive heat is critical to prevent degradation of the active compounds.
Ingredients / Composition
The classic Wockhardt formulation per 5mL is typically documented as containing: Promethazine Hydrochloride (6.25 mg) and Codeine Phosphate (10 mg), equivalent to Codeine base (9.75 mg). The solution includes inactive ingredients such as citrate sodium, glycerin, sodium benzoate, sucrose, and others, which are relevant for full compositional analysis. The exact ratio and composition make it a distinct entity for spectroscopic and chromatographic fingerprinting.
Usage Areas for Research & Educational Purposes
In a strictly legal and regulated environment, a reference standard of this nature has defined applications. These include: Analytical Chemistry – serving as a calibration standard for drug identification and quantification in forensic toxicology; Pharmacological Education – illustrating drug-drug interaction principles, metabolic pathways (CYP2D6), and receptor pharmacology; Regulatory Science – comparing formulation consistency and degradation profiles. It is emblematic of the critical need for precise standards in pharmaceutical science. For information on legitimate pharmaceutical education resources, one can visit the homepage at https://healthaidpharmacy.com/.
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