What is Foundayo used for?
Foundayo (orforglipron) is commonly used for weight loss and long-term weight management in people who have obesity or overweight with one or more weight-related health conditions.
Learn more about how Foundayo works for weight loss.
Foundayo may also be used for other conditions as determined by your health care provider.
How does Foundayo work (mechanism of action)?
Foundayo works by acting like a natural hormone in your body called glucagon-like peptide-1 (GLP-1). This hormone helps control your appetite. Foundayo attaches to GLP-1 receptors, which are found in parts of the brain that help control hunger. By turning on these receptors, it helps reduce appetite and may help you eat less.
How is Foundayo supplied (dosage forms)?
Brands and other names
- Foundayo
Dosage forms and strengths
- 0.8 mg, 2.5 mg, 5.5 mg, 9 mg, 14.5 mg, 17.2 mg oral tablets
How should I store Foundayo?
Store Foundayo at room temperature, between 68 F and 77 F (20 C and 25 C). It can be exposed to temperatures between 59 F and 86 F (15 C and 30 C) for shorter periods of time, such as when transporting it. Keep Foundayo in the original bottle and carton with the lid on to protect the medicine from light.
Side Effects
What are the most common side effects of Foundayo?
The most common side effects of Foundayo are listed below. Tell your health care provider if you have any of these side effects that bother you.
- Nausea
- Constipation or diarrhea
- Vomiting
- Stomach pain, upset stomach, or indigestion
- Headache
- Stomach bloating, belching, or gas
- Tiredness
- Acid reflux
- Hair loss
There may be other side effects of Foundayo that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088 (800-332-1088). In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.
What are the serious side effects of Foundayo?
While less common, the most serious side effects of Foundayo are described below, along with what to do if they happen.
Severe Allergic Reactions. Foundayo may cause allergic reactions, which can be serious. Stop taking Foundayo and get help right away if you have any of the following symptoms of a serious allergic reaction.
- Breathing problems or wheezing
- Racing heart
- Fever or general ill feeling
- Swollen lymph nodes
- Swelling of the face, lips, mouth, tongue, or throat
- Trouble swallowing or throat tightness
- Itching or skin rash
- Bumps on the skin called hives that can be red, pink, white, or brown depending on your skin tone
- Nausea or vomiting
- Dizziness, feeling lightheaded, or fainting
- Stomach cramps
- Joint pain
Thyroid Tumors. Foundayo may cause thyroid tumors. Some of these tumors could be cancerous. Tell your health care provider right away if you notice any of the following symptoms of a thyroid tumor.
- Swelling or a lump in your neck
- Hoarseness
- Trouble swallowing or breathing
Pancreatitis. Foundayo may cause inflammation of the pancreas (pancreatitis). Stop taking Foundayo and call your health care provider right away if you have symptoms of pancreatitis, including vomiting or severe pain in the upper part of your belly that travels to your back.
Severe Stomach Problems. Severe stomach problems may happen with Foundayo. Call your health care provider if you have nausea, vomiting, or diarrhea that is severe or does not go away.
Gallbladder Problems. Foundayo may cause gallbladder problems, including cholecystitis and cholelithiasis (also known as gallstones). Call your health care provider right away if you have any of the following symptoms.
- Your skin or the whites of your eyes turning yellowish in color (also called jaundice)
- Fever
- Pain in your upper stomach area
- Stool (poop) that is clay-colored
Low Blood Sugar (Hypoglycemia). Foundayo may cause low blood sugar, especially when used with insulin or other medicines that increase insulin levels. Hypoglycemia can be serious and may lead to death if left untreated. Call your health care provider right away if you have any of the following symptoms of hypoglycemia.
- Headache
- Crankiness or anxiety
- Hunger
- Dizziness or confusion
- Blurry vision
- Slurred speech
- Sweating
- Feeling jittery or shakiness
- Fast heartbeat
- Seizures
Dehydration. Foundayo may cause diarrhea, nausea, and vomiting, which may lead to dehydration. Dehydration may cause kidney damage. If you have nausea, vomiting, or diarrhea, drink plenty of water so that you do not get dehydrated. Call your health care provider right away if you have severe vomiting or diarrhea that will not go away or any of the following symptoms of kidney damage.
- Weakness or unusual tiredness
- Confusion
- Peeing less than normal
- Swelling in your legs, ankles, and feet
- Loss of appetite or nausea
- A hard time catching your breath or chest pain or pressure
- Seizures
- Extreme thirst
Warnings & Precautions
Who should not take Foundayo?
Allergies to Ingredients. People who are allergic to any of the following should not take Foundayo.
- Foundayo
- Orforglipron
- Any of the ingredients in the specific product dispensed
Your pharmacist can tell you all of the ingredients in Foundayo.
Thyroid Cancer or Endocrine Condition. Foundayo should not be used if you or someone in your family has had medullary thyroid carcinoma (MTC) or if you have a condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Tell your health care provider about your current and past health conditions and your family medical history.
What should I know about Foundayo before taking it?
Do not take Foundayo unless it has been prescribed to you by a health care provider. Take it as prescribed.
Do not share Foundayo with other people, even if they have the same condition as you. It may harm them.
Keep Foundayo out of the reach of children.
Swallow Foundayo whole. Do not cut, crush, or chew it.
What should I tell my health care provider before taking Foundayo?
Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them know if Foundayo is right for you.
In particular, make sure that you discuss any of the following.
Upcoming Surgery or Procedure. Tell your health care provider that you take Foundayo before any planned surgeries or procedures that require anesthesia or deep sedation. Foundayo may cause your stomach to empty more slowly, which can increase the risk of food getting into your lungs (aspiration) during surgery or procedures.
Vision Problems. Tell your health care provider if you have diabetic retinopathy or have had diabetes-related vision problems. You may need to have your vision checked while taking Foundayo.
Other Current and Past Health Conditions. Tell your health care provider if you have any of the following.
- Digestion problems or slowed stomach emptying (gastroparesis)
- Pancreas or gallbladder problems
- Kidney or liver problems
Other Medicines and Supplements. Foundayo may interact with other medicines and supplements. Before taking Foundayo, tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.
Pregnancy. Foundayo may cause harm to a fetus. If you can become pregnant, you should use effective birth control while taking Foundayo. Talk to your health care provider about your birth control options. Tell your health care provider if you are pregnant or plan to become pregnant. If you become pregnant, stop taking Foundayo and contact your health care provider right away. You can also register for the Foundayo Pregnancy Registry by calling 800-545-5979. This registry collects information about the use of Foundayo during pregnancy.
Breastfeeding. It is not known if Foundayo passes into breast milk. Breastfeeding is not recommended while taking Foundayo. Tell your health care provider if you are breastfeeding or plan to breastfeed. Your health care provider will let you know if you should take Foundayo while breastfeeding.
How can I get more information about Foundayo?
For more information about Foundayo, you can visit the drugmaker’s website at www.foundayo.lilly.com or call them at 800-545-5979.
Interactions
Does Foundayo interact with foods or drinks?
There are no known interactions between Foundayo and foods or drinks.
It is unknown if drinking alcohol will affect Foundayo.
Does Foundayo interact with other medicines (drug interactions)?
Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.
In particular, make sure that you discuss if you are using any of the following before taking Foundayo.
- Any other GLP-1 agonist, such as semaglutide (Ozempic, Wegovy), which is a medicine commonly used for type 2 diabetes or weight loss
- Clarithromycin, which is a medicine used for bacterial infections
- Carbamazepine (Carbatrol, Tegretol, and others), which is a medicine commonly used to treat seizures or nerve pain
- Cyclosporine (Gengraf, Neoral, Sandimmune, and others), which is a medicine that suppresses your immune system
- Insulin, which is a medicine used for diabetes
- A sulfonylurea, such as glimepiride, glipizide, or glyburide, which is a medicine used for type 2 diabetes
- Simvastatin (Zocor), which is a medicine to lower cholesterol
Some other medicines may alter the blood levels of Foundayo, and vice versa. Foundayo may also affect the absorption of some other medicines. Tell your health care provider about all medicines that you take or have recently taken. In particular, make sure you tell your health care provider if you take a birth control pill.
This may not be a complete list of medicines that can interact with Foundayo. Always check with your health care provider.
